|First appearance in comic||
In the comic
Serafine first appears in "Hatchetman". It is revealed via flashback that shortly before the timeframe of the comic, Serafine, Mordecai and Nico are involved in a situation that creates a "high-profile" mess. Serafine suggests that they turn to the pig farmers for assistance, and Nico notes that the pigs "eat anything".
Serafine next appears in the Hotel Maribel in "Cutthroat". Asa and Mordecai discuss how Nico and Serafine came to work for Asa. He tells Mordecai that, "we dredged them out of the bayous", where they had been working for a small bootlegging operation. Asa and his associates consequently hired them and they have proven very efficient, so much so that Nico and Serafine have been assigned to accompany Mordecai while he pursues "other ventures" for Asa and his associates.
Appearance and personality
Serafine was born in New Orleans between October 25 and November 1, 1902, making her 25 years old at the time of the comic. Serafine's height is approximately 5'6". Serafine and Nico were not raised by their parents. According to Tracy, Serafine did not complete her primary education. Her favorite food is extremely spicy gumbo or jambalaya.  Serafine appears to enjoy dressing in a both upper-class and somewhat masculine manner. In "Hatchetman" she is wearing a suit and tie. She is a self-proclaimed voodoo priestess with a fondness for an automatic rifle named Boudreaux.
Serafine is currently employed by Asa and his associates.
Nico is Serafine's brother.